Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
Spike has a 100% Correlation to Symptomatic Myocarditis, but NOT Necessarily Causative 🧐
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025
I was forwarded this whopper of a paper via Discord yesterday (Thanks MaryContrary) and wanted to take you through some of the most salient points uncovered about myocarditis diagnoses, how spike is involved, as well as how other pathologies are occurring that are non-spike related due to the vaccine.
"A notable finding was that markedly elevated levels of full-length spike protein, unbound by antibodies, were detected in the plasma of individuals with postvaccine myocarditis, whereas no free spike was detected in asymptomatic vaccinated control subjects."
Free spike circulating within the heart was detected in 100% of myocarditis patients. Free spike means antibodies are NOT bound to the immunogen (antigen produced by vaccine). Whereas antibody free spike was in all symptomatic cases of myocarditis, antibody bound spike was found in asymptomatic vaccinated control subjects
"both free and antibody-bound spike, which was detectable only in patients who developed vaccine-induced myocarditis, remained detectable up to 3 weeks after vaccination"
Myocarditis patients had BOTH free and antibody bound spike in their systems in a detectable range for 3 weeks. This is the first published indication I have seen as to the half-life of the spike itself within the system. However, Dr. Peter McCullough has also noted the mRNA itself remains detectable for at least 2 months; not to mention the complete lack of pharmacokinetics or mechanisms of Lipid nanoparticle (LNP) elimination, which surround each mRNA.
"The persistence of circulating spike in patients with postvaccine myocarditis is similar to the SARS-CoV-2 antigenemia previously reported to be a pathogenic feature of MIS-C"
The pathogenic feature of Multi-system Inflammation Syndrome due to Covid (MIS-C) is the prevalence of SARS-CoV-2 antigens (spike) in various organs of the body. A diagnosis of “multi-system” means more than one, whereas the diagnosis of Myocarditis is singularly focused to the heart. Antigenemia being observed in Myocarditis as well as MIS-C is an indication of what MIS-C is when the heart is involved.
Antigenemia = The presence of antigens (especially viral antigens) in the bloodstream.(countable and uncountable, plural antigenemias) (pathology, immunology) . In the case of vaccines, the spike proteins produced are called “immunogens”.
"Although both MIS-C and postvaccine myocarditis resulted in elevated cardiac troponin T and CRP compared with healthy vaccinated control subjects, when MIS-C was compared with postvaccine myocarditis, cardiac troponin T levels were significantly elevated for the myocarditis cohort, and CRP levels were significantly elevated for the MIS-C cohort."
Differences in troponin T and CRP levels indicate separate mechanistic pathologies of MIS-C and postvaccine Myocarditis. Meaning that although both are clinically cases warranting a diagnoses of Myocarditis, the mechanisms involved on the cellular level are different.
"our data suggest that there is a potentially unique mechanism of myocardial injury after SARS-CoV-2 mRNA vaccination associated with a robust innate immune response."
A robust innate immune response is being triggered in the myocardium that is NOT SARS-CoV-2 antigen related. Observations of natural infection differ from vaccination to the point where the vaccination itself is seen to be the cause of its own pathogenesis. This is the first clear indication I have read that vaccination technology itself may produce pathogenic effects in the body INDEPENDENT of whatever immunogen is being produced.
"in MIS-C, the superantigen-like motif of spike/S1 engages with the immune system to produce T-cell receptor skewing and a profound hyperinflammatory response; in postvaccine myocarditis, the circulating free spike antigen appears to evade antibody recognition."
Evading antibody recognition, in addition to T-cell receptor skewing and a profound hyperinflammatory response are associated with postvaccine myocarditis, whereas MIS-C was NOT able to evade antibody recognition. There are 3 possibilities or a combination here:
Preexisting or genetic Immune dysfunction in the Myocarditis group the authors never postulated existed that caused their bodies to NOT process antibodies that would bind to spike.
There is a form of immune system dysregulation occurring due to the vaccine allowing for spike immunogens to evade antibody recognition.
Spike was being produced directly in the heart due to LNP migration from the injection site, and where no preexisting antibodies were present.
Whereas #1 is a possibility, it is highly unlikely. Although another way of phrasing this possibility would be the dysfunction of not being previously infected and thus no possibility of the presence of antibodies.
A combination of 2 & 3 appears to be more likely. When it comes to evading immunity, we have to remember the methyl-pseudouridines aligning the entire genetic code of the mRNA within the LNPs was specifically designed to “evade” toll like receptors (TLR) of the innate immune system. However, I have also come across a statement from Dr. Sharon Tenpenny alluding to methyl-pseudouridines ability to “oblate” (i.e. destroy) TLRs.
TLRs are also called Damage Activated Molecular Process (DAMP) and Pathogen Activated Molecular Process (PAMP). In essence these are the receptors your innate immune system uses to detect whether damage needs to be repaired, or if there is another organism that needs to be addressed. If the methyl-pseudouridines are destroying the TLRs then the innate immune system will never be activated to process the immunogen into smaller pieces, so it may then be handed off to the adaptive immune system where antibodies are made. In essence, the reason spike is unbound by antibodies in Myocarditis cases is because the innate immune system is being destroyed locally, in a paracrine fashion.
The idea of locally affected TLRs in the heart would then have to be associated with either LNP or mRNA migration from the injection site. The idea all of the injection stays in the arm has already been exposed as false. We live in a world where the acknowledgment of LNP migration to various organs in the body is well documented.
What is NOT well documented is the effect LNPs would have in eliciting their own cascade of pathogenesis leading to cellular death (apoptosis/pyroptosis). I have dedicated a previous article specifically to cationic apoptosis due to LNPs and may be viewed here:
It is important to bring back the takeaway from the author that there is a separate pathway in vaccine related Myocarditis as opposed to MIS-C; although both showed the presence of free spike within the heart. I find it much more likely that LNP migrated to the heart after injection, mRNA began producing spike and eliminating TLRs, until they reach a concentration where hyperinflammation expresses itself in the heart as Myocarditis.
"It is notable that spike, which remained intact by evading cleavage and clearance, was associated with myocarditis in this cohort. Whether the circulating spike protein in the setting of mRNA vaccination was pathogenic is unclear. In postvaccine myocarditis, the spike protein appears to evade antibody recognition because the anti-spike antibodies that are generated are produced in adequate quantities with normal functional and neutralization capacity. There is growing in vitro evidence that spike itself can stimulate cardiac pericytes dysfunction or inflame the endothelium, potentially by downregulating angiotensin-converting enzyme 2 expression, by impairing endothelial nitric oxide bioavailability, or by activating integrin-mediated inflammation with hyperpermeability of the endothelial cell layer. Thus, the spike antigen itself, which evades antibody recognition rather than invoking immune hyperactivation, may contribute to myocarditis in these individuals."
Returning back to the spike protein. It is disconcerting how the authors relate specific pathologies to the spike protein, but somehow stop short of calling it either toxic or causative of Myocarditis. In essence, what they have said is the spike is NOT “necessarily” the causative agent of Myocarditis; but that it is 100% correlated to the diagnosis of Myocarditis and MIS-C...
American Foundation for Informed Consent will be expanding into compulsory reporting of spike itself as a biologic toxin. Click the GiveSendGo to support.
https://www.givesendgo.com/AmericanFoundationforInformedConsent
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
The Yonker report has a major problem.
The myocarditis patients circulating spike samples are much earlier than the ones from the uninjured, but when you compare with ogata et al, it is much more in line.
The circulating spike hypothesis is falsifiable in multiple ways. The most obvious aren't antibodies actually doing the working. If Tcells are primed how can any amount of spike be produced given the speed of Tcell intervention at jab 2 and plus?
But more importantly w
How do spike bypass the vasculaf system's disseminative qualities?
It can't. Circulating spike issued should be in the tissue and in the vein, snd disseminated, ie systemic not in the aorta.
Zn dit would not give rise to Tcell attacks.